Every time I think about how tragic the European conquest of the Americas was, I get sad. No matter what the Europeans did, if every single person who left Europe for America had been a saint who was dedicated to preserving and protecting the cultural integrity of Native Americans, I don't think history would have changed much. There were just too many endemic Eurasian diseases to which Native Americans had absolutely no immunity to have materially changed what happened. The Eurasian landmass was just too big, too populated, had too many diseases, and was so genetically diverse for the Native Americas to have stood a chance. This in no way excuses the atrocities the European invaders committed. It's just an acknowledgement that the European's malice had minimal effect. The adverse impacts of European diseases spread far faster, far wider, and were far deadlier than anything European malice could ever hope to accomplish.
It was a war where one side was shooting arrows and throwing spears and the other side was dropping nuclear bombs.