Scientists reverse Alzheimer's in mice

[CarolinaFever]

Using diverse preclinical mouse models and analysis of human AD brains, the team showed that the brain’s failure to maintain normal levels of a central cellular energy molecule, NAD+, is a major driver of AD, and that maintaining proper NAD+ balance can prevent and even reverse the disease.

New study shows Alzheimer’s disease can be reversed to achieve full neurological recovery—not just prevented or slowed—in animal models | CWRU Newsroom | Case Western Reserve University

For more than a century, people have considered Alzheimer's disease (AD) an irreversible illness. Consequently, research has focused on preventing or ...

case.edu

 

[ChileG]

Thank you for sharing. Alzheimer’s runs in my mother’s side of the family especially with women. It killed my mom. I hope they can duplicate this in humans.

 

[dcf2]

The manuscript summary:

Alzheimer’s disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer’s neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

 

[finesse]

How far would something like this be realized for human use generally speaking? I'm guessing that there are a lot of variables and a fair chance that it can't currently be done.

 

[CarolinaFever]

How far would something like this be realized for human use generally speaking? I'm guessing that there are a lot of variables and a fair chance that it can't currently be done.

Maybe not now but it does sound very promising for the future.

 

[heelinhell]

Thank you for sharing. Alzheimer’s runs in my mother’s side of the family especially with women. It killed my mom. I hope they can duplicate this in humans.

My mother and maternal grandmother suffered from Alzheimer's so I assume I am genetically loaded to suffer the same. I am 74yo and my mom had early onset in her early 60's so I console myself with the possibility I will dodge the dementia bullet .

There have been advances in slowing down the process so I am hoping I will continue to " stay afloat " as treatments come to the fore.

It would be so wonderful if a cure is found in the next 20 years to eliminate the risk for my adult children.

 

[doctor_octopus]

 

[05C40]

My mother and maternal grandmother suffered from Alzheimer's so I assume I am genetically loaded to suffer the same. I am 74yo and my mom had early onset in her early 60's so I console myself with the possibility I will dodge the dementia bullet .

There have been advances in slowing down the process so I am hoping I will continue to " stay afloat " as treatments come to the fore.

It would be so wonderful if a cure is found in the next 20 years to eliminate the risk for my adult children.

My family history is so mixed that I have no idea what awaits me in the coming decade. My mother died in her mid-60's, almost certainly as a result of being a two pack-a-day cigarette smoker her entire adult life. My father lived to 82 and only developed memory/cognitive problems a few years before his death, despite having a brain full of shrapnel that he collected on Guadalcanal in 1942. My grandparents varied from dying in the early 60's from smoking or living until there early to mid 80's and only developing cognitive problems until the final years. I'm a never-smoker, don't have any shrapnel in my brain, and have the benefit of modern medical care, so I've got all that going for me.