Spanish scientist finds cure for pancreatic cancer in major medical breakthrough

One of my neighbors was just diagnosed. He just started a clinical trial at Hopkins.
 

Abstract​

Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies, although their beneficial effect is still limited mainly due to the rapid appearance of tumor resistance. Here, we demonstrate that genetic ablation of three independent nodes involved in downstream (RAF1), upstream (EGFR), and orthogonal (STAT3) KRAS signaling pathways leads to complete and permanent regression of orthotopic PDACs induced by KRAS/TP53 mutations. Likewise, a combination of selective inhibitors of KRAS (RMC-6236/daraxonrasib), EGFR family (afatinib), and STAT3 (SD36) induced the complete regression of orthotopic PDAC tumors with no evidence of tumor resistance for over 200 d posttreatment. This combination therapy also led to significant regression of genetically engineered mouse tumors as well as patient-derived tumor xenografts (PDX) in the absence of tumor relapses. Of importance, this combination therapy was well tolerated. In sum, these results should guide the development of new clinical trials that may benefit PDAC patients.
 
That’s great news. Looks like the combination includes one drug approved in the US (afatinib) and two investigational drugs (daraxonrasib and SD36). These are all narrowly targeted so in addition to being theoretically more efficacious in humans, they should also be much more tolerable than the conventional chemo we currently use for pancreatic cancer.
 
The only person I’ve heard of who had pancreatic cancer and doctors were able to treat it is Eric Idle. And that’s only because they found it in a very early stage while they were checking something else.
 
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