Experts suggest the strike - which killed 11 alleged cartel members - may be illegal under international law.
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BBC Verify reached out to a range of experts in international and maritime law, with several saying that US may have acted illegally
in attacking the vessel.
The US is not a signatory to United Nations Convention on the Law of the Sea, but the US military's legal advisors have previously said that the US
should "act in a manner consistent with its provisions".
Under the convention, countries agree not to interfere with vessels operating in international waters. There are limited exceptions to this which allow a state to seize a ship, such as a "hot pursuit" where a vessel is chased from a country's waters into the high seas.
"Force can be used to stop a boat but generally this should be non-lethal measures," Prof Luke Moffett of Queens University Belfast said.
But he added that the use of aggressive tactics must be "reasonable and necessary in self-defence where there is immediate threat of serious injury or loss of life to enforcement officials", noting that the US moves were likely "unlawful under the law of the sea".
Are US strikes on alleged cartel members legal?
Experts have also questioned whether the killing of the alleged members of the Tren de Aragua cartel could contravene international law on the use of force.
Under Article 2(4) of the UN charter, countries can resort to force when under attack and deploying their military in self-defence. Trump has previously accused the Tren de Aragua cartel of conducting irregular warfare against the US, and the state department has
designated the group as a Foreign Terrorist Organisation.
But Prof Michael Becker of Trinity College Dublin told BBC Verify that the US actions "stretches the meaning of the term beyond its breaking point".
"The fact that US officials describe the individuals killed by the US strike as narco-terrorists does not transform them into lawful military targets," he said. "The US is not engaged in an armed conflict with Venezuela or the Tren de Aragua criminal organization."
"Not only does the strike appear to have violated the prohibition on the use of force, it also runs afoul of the right to life under international human rights law."
Prof Moffett said that the use of force in this case could amount to an "extrajudicial arbitrary killing" and "a fundamental violation of human rights".
"Labelling everyone a terrorist does not make them a lawful target and enables states to side-step international law," he said.