If Trump wins, perhaps. But if Trump loses, I don’t see it. When is the last time, if ever, a VP candidate on a losing ticket has been a real threat politically?
In my lifetime, there was Dole, Mondale, Bentsen, Quayle, Lieberman, Edwards, Palin, Ryan, Kaine, and Pence. Of those, only two were able to go on to become their party’s nominee for President, but each time they were essentially sacrificial lambs, nominated to run when everyone knew that had no real chance. And Vance will have that Trump taint on him.