People With Severe Diabetes Are Cured in Small Trial of New Drug

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evrheel

evrheel

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https://www.nytimes.com/2025/06/20/health/diabetes-cure-insulin-stem-cell.html

A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much lower doses.

The experimental treatment, called zimislecel and made by Vertex Pharmaceuticals of Boston, involves stem cells that scientists prodded to turn into pancreatic islet cells, which regulate blood glucose levels. The new islet cells were infused and reached the liver, where they took up residence.
 
evrheel said:
https://www.nytimes.com/2025/06/20/health/diabetes-cure-insulin-stem-cell.html

A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much lower doses.

The experimental treatment, called zimislecel and made by Vertex Pharmaceuticals of Boston, involves stem cells that scientists prodded to turn into pancreatic islet cells, which regulate blood glucose levels. The new islet cells were infused and reached the liver, where they took up residence.
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Would be a game-changer if this proves out in wider studies.
 
evrheel said:
https://www.nytimes.com/2025/06/20/health/diabetes-cure-insulin-stem-cell.html

A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much lower doses.

The experimental treatment, called zimislecel and made by Vertex Pharmaceuticals of Boston, involves stem cells that scientists prodded to turn into pancreatic islet cells, which regulate blood glucose levels. The new islet cells were infused and reached the liver, where they took up residence.
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My goodness
Where do I but their stock
 
"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.
 
superrific said:
"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.
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Right, so obviously we should shut down Harvard and slash R&D funding.
 
superrific said:
"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.
Click to expand...
In fairness, MAGA is more of the Type 2 diabetes cohort.
 
My sister developed type 1 diabetes in her 40s. This would be a life-changing breakthrough for many people.
 
superrific said:
"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.
Click to expand...
 
From NEJM this week:

A total of 14 participants (2 in part A and 12 in parts B and C) completed at least 12 months of follow-up and were included in the analyses. C-peptide was undetectable at baseline in all 14 participants. After zimislecel infusion, all the participants had engraftment and islet function, as evidenced by the detection of C-peptide. Neutropenia was the most common serious adverse event, occurring in 3 participants. Two deaths occurred — one caused by cryptococcal meningitis and one by severe dementia with agitation owing to the progression of preexisting neurocognitive impairment. All 12 participants in parts B and C were free of severe hypoglycemic events and had a glycated hemoglobin level of less than 7%; these participants spent more than 70% of the time in the target glucose range (70 to 180 mg per deciliter). Ten of the 12 participants (83%) had insulin independence and were not using exogenous insulin at day 365.
 
lawtig02 said:
These are the things that, in a rational world, would get the A, B and C blocks of the nightly news. But alas. Thanks, MAGA.
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Wait till the MAHA crowd decides it’s a form of body/mind control and gears up to fight the approval.
 
evrheel said:
Vertex, like other drug companies, declined to announce the treatment’s cost before the Food and Drug Administration approves it.
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no where close to being able to price it
www.biospace.com

Vertex’s Cell Therapy Could Be ‘Functional Cure’ for Diabetes, but Market Prospects Uncertain

While BMO Capital Markets said that zimislecel is “highly encouraging” for type 1 diabetes, questions regarding its target population and Vertex’s execution hang over the cell therapy’s commercial potential.
www.biospace.com www.biospace.com
 
lawtig02 said:
Well, if we learned anything positive from Trump 1.0, it's that he knows how to fast track beneficial pharmaceuticals.
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???? If you're talking about the Covid vaccine development, that was he result of mRNA technology development, which Trump had nothing to do with and RFK jr would have killed, had he had the chance.
 
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