People With Severe Diabetes Are Cured in Small Trial of New Drug

[evrheel]

https://www.nytimes.com/2025/06/20/health/diabetes-cure-insulin-stem-cell.html

A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much lower doses.

The experimental treatment, called zimislecel and made by Vertex Pharmaceuticals of Boston, involves stem cells that scientists prodded to turn into pancreatic islet cells, which regulate blood glucose levels. The new islet cells were infused and reached the liver, where they took up residence.

 

[nycfan]

https://www.nytimes.com/2025/06/20/health/diabetes-cure-insulin-stem-cell.html

A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much lower doses.

The experimental treatment, called zimislecel and made by Vertex Pharmaceuticals of Boston, involves stem cells that scientists prodded to turn into pancreatic islet cells, which regulate blood glucose levels. The new islet cells were infused and reached the liver, where they took up residence.

Would be a game-changer if this proves out in wider studies.

 

[mpaer]

https://www.nytimes.com/2025/06/20/health/diabetes-cure-insulin-stem-cell.html

A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much lower doses.

The experimental treatment, called zimislecel and made by Vertex Pharmaceuticals of Boston, involves stem cells that scientists prodded to turn into pancreatic islet cells, which regulate blood glucose levels. The new islet cells were infused and reached the liver, where they took up residence.

My goodness
Where do I but their stock

 

[evrheel]

My goodness
Where do I but their stock

Vertex, like other drug companies, declined to announce the treatment’s cost before the Food and Drug Administration approves it.

 

[superrific]

"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.

 

[Duke Mu]

"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.

Right, so obviously we should shut down Harvard and slash R&D funding.

 

[Calheel]

"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.

In fairness, MAGA is more of the Type 2 diabetes cohort.

 

[PTOHeel]

My sister developed type 1 diabetes in her 40s. This would be a life-changing breakthrough for many people.

 

[dcf2]

"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.

 

[dcf2]

From NEJM this week:

A total of 14 participants (2 in part A and 12 in parts B and C) completed at least 12 months of follow-up and were included in the analyses. C-peptide was undetectable at baseline in all 14 participants. After zimislecel infusion, all the participants had engraftment and islet function, as evidenced by the detection of C-peptide. Neutropenia was the most common serious adverse event, occurring in 3 participants. Two deaths occurred — one caused by cryptococcal meningitis and one by severe dementia with agitation owing to the progression of preexisting neurocognitive impairment. All 12 participants in parts B and C were free of severe hypoglycemic events and had a glycated hemoglobin level of less than 7%; these participants spent more than 70% of the time in the target glucose range (70 to 180 mg per deciliter). Ten of the 12 participants (83%) had insulin independence and were not using exogenous insulin at day 365.

 

[Healing]

"The treatment is the culmination of work that began more than 25 years ago when a Harvard researcher, Doug Melton, vowed to find a cure for type 1 diabetes. His 6-month-old baby boy developed the disease and, then, so did his adolescent daughter. His passion was to find a way to help them and other patients."

Take note, MAGA, of what you're destroying.

In fairness, MAGA is more of the Type 2 diabetes cohort.

Inverse vaccines have shown promise treating type I, multiple sclerosis, and some other autoimmune diseases. ‘Inverse vaccines’: the promise of a ‘holy grail’ treatment for autoimmune diseases

“The study looked at celiac disease, in which the immune system attacks the intestinal lining when it detects the presence of gluten, a protein found in wheat and other grains.

Over two weeks, 33 celiac patients who were in remission ingested gluten; about half had received the inverse vaccine beforehand, while the other half got a placebo. After two weeks, researchers examined the subjects’ intestinal lining and found that the inverse vaccine group had no damage, while the placebo group showed a noticeable worsening of symptoms.

The basic idea of inverse vaccines rests on using certain synthetic nanoparticles attached to particular disease-related proteins – called antigens – as targeted messengers to retrain the immune system. The nanoparticles mimic dying human cells, a normal ongoing process. Although these dying cells are “foreign”, the immune system knows not to attack them. The immune system learns to ignore both the nanoparticles and the attached proteins, and stops attacking the body.

In 2023, Hubbell and his colleagues published a peer-reviewed paper in Nature showing that this method could halt the mouse version of multiple sclerosis (MS), a disease in which the immune system attacks nerve cells in the brain and body. Over the past eight months, Anokion, the company started by Hubbell and others to commercialize their work, has announced successful early trials in humans in both celiac disease and MS.”

We can only hope maga doesn’t fuck this up for everyone.

 

[lawtig02]

These are the things that, in a rational world, would get the A, B and C blocks of the nightly news. But alas. Thanks, MAGA.

 

[Geisterfahrer]

These are the things that, in a rational world, would get the A, B and C blocks of the nightly news. But alas. Thanks, MAGA.

Wait till the MAHA crowd decides it’s a form of body/mind control and gears up to fight the approval.

 

[Batt Boy]

Vertex, like other drug companies, declined to announce the treatment’s cost before the Food and Drug Administration approves it.

no where close to being able to price it

Vertex’s Cell Therapy Could Be ‘Functional Cure’ for Diabetes, but Market Prospects Uncertain

While BMO Capital Markets said that zimislecel is “highly encouraging” for type 1 diabetes, questions regarding its target population and Vertex’s execution hang over the cell therapy’s commercial potential.

www.biospace.com

 

[Batt Boy]

at best, it's 6 years away from any potential approval

 

[lawtig02]

at best, it's 6 years away from any potential approval

Well, if we learned anything positive from Trump 1.0, it's that he knows how to fast track beneficial pharmaceuticals.

 

[breepf]

Oh sure, Harvard only deigns to cure elite east-coast Type 1 diabetes.

 

[evrheel]

Well, if we learned anything positive from Trump 1.0, it's that he knows how to fast track beneficial pharmaceuticals.

???? If you're talking about the Covid vaccine development, that was he result of mRNA technology development, which Trump had nothing to do with and RFK jr would have killed, had he had the chance.