Just curious - how and why do you think this will come to pass? That we will use technology to alter ourselves biologically?
Or do you mean more along the lines of human civilization in 500 years will be unrecognizable to us today?
I don't know. I'm just going with the trend. Technology moves so much faster than human life now. People just can't keep up.
Humans take about 20 years to form into adulthood, and then after reaching age 30 or so, are basically static in terms of outlook or world view for the next 50.
On a technology time line, 20 years ago is forever. It was pre-iPad. And change is getting faster and faster. ChatGPT is what, four years old, and it's already laying waste to our educational systems (according to many teachers/professors). And now that AI can help program AI . . .
These are all very humdrum insights so I won't go on about them. The point is that humans cannot keep up. We evolved in stable environments where change was slow. Even late in our evolution, even a thousand years ago -- what a person learned as a child was useful and valid for all of life. Even our transformational periods, like the Renaissance, played out over generations. Take any given 50 year period prior to the Industrial Revolution and life at the end of it was more or less the same as life prior to, with some minor modifications. In the 20th century, change accelerated but it was still gradual. Life at the end of a decade was generally the same as at the beginning (not counting specific events like war). Now things change practically year to year.
So projecting out 500 years, I have no way of knowing what will happen but the change vector is so steep that I do not think humans will be able to cope. Maybe we all kill each other, or we have mass starvation, or we become siliconized, or who knows but we are not adapted to having our world completely rewritten every few years.